Reprogramming progeria fibroblasts re‐establishes a normal epigenetic landscape

  title={Reprogramming progeria fibroblasts re‐establishes a normal epigenetic landscape},
  author={Zhaoyi Chen and Wing Y. Chang and Alton Etheridge and Hilmar Strickfaden and Zhigang Jin and Gareth A. Palidwor and Ji-Hoon Cho and Kai Wang and Sarah Y Kwon and Carole Dor{\'e} and Angela Raymond and Akitsu Hotta and James Ellis and Rita A Kandel and F Jeffrey Dilworth and Theodore J. Perkins and Michael J. Hendzel and David J. Galas and William L. Stanford},
  booktitle={Aging cell},
Ideally, disease modeling using patient-derived induced pluripotent stem cells (iPSCs) enables analysis of disease initiation and progression. This requires any pathological features of the patient cells used for reprogramming to be eliminated during iPSC generation. Hutchinson-Gilford progeria syndrome (HGPS) is a segmental premature aging disorder caused by the accumulation of the truncated form of Lamin A known as Progerin within the nuclear lamina. Cellular hallmarks of HGPS include nuclear… CONTINUE READING
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