Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability.

@article{Marui1997ReprogrammingOT,
  title={Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability.},
  author={L. Maru{\vs}i{\'c} and Martina Anton and Alwynne Tidy and Huangzhen Wang and Bryant Villeponteau and Silvia Bacchetti},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 11},
  pages={6394-401}
}
Telomerase synthesizes telomeric DNA by copying the template sequence of its own RNA component. In Tetrahymena thermophila and yeast (G. Yu, J. D. Bradley, L. D. Attardi, and E. H. Blackburn, Nature 344:126-131, 1990; M. McEachern and E. H. Blackburn, Nature 376:403-409, 1995), mutations in the template domain of this RNA result in synthesis of mutant telomeres and in impaired cell growth and survival. We have investigated whether mutant telomerase affects the proliferative potential and… CONTINUE READING

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