Reprogramming of somatic cells via TAT-mediated protein transduction of recombinant factors.

@article{Zhang2012ReprogrammingOS,
  title={Reprogramming of somatic cells via TAT-mediated protein transduction of recombinant factors.},
  author={Hui Zhang and Yu Ma and Junjie Gu and Bing Mana Liao and Jiwen Li and Jiemin Wong and Ying Jin},
  journal={Biomaterials},
  year={2012},
  volume={33 20},
  pages={5047-55}
}
Generation of induced pluripotent stem cells (iPSCs) holds great promise to regenerative medicine. However, before this technology can be applied for clinical purpose, the issues of iPSC efficiency and safety need to be addressed. In this study, we have compared a simple TAT- and 11 arginine (R)-protein transduction domain (PTD) for somatic cell reprogramming and explored the optimal conditions for the PTD to transduce reprogramming factors (RFs). We show that all recombinant TAT- and 11R-fused… CONTINUE READING
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