Reprogramming of human fibroblasts into multipotent cells with a single ECM proteoglycan, fibromodulin.
@article{Zheng2012ReprogrammingOH, title={Reprogramming of human fibroblasts into multipotent cells with a single ECM proteoglycan, fibromodulin.}, author={Zhong Zheng and Jia Jian and Xinli Zhang and Janette N. Zara and Wei Yin and Michael F. Chiang and Yi Liu and Joyce Z. Wang and Shen Pang and Kang Ting and Chia Soo}, journal={Biomaterials}, year={2012}, volume={33 24}, pages={ 5821-31 } }
58 Citations
CDKN2B upregulation prevents teratoma formation in multipotent fibromodulin-reprogrammed cells.
- Biology, MedicineThe Journal of clinical investigation
- 2019
A novel, protein-based reprogramming method that does not require genome integration or oncogene activation to yield multipotent fibromodulin (FMOD)-reprogrammed (FReP) cells from dermal fibroblasts is established and it is shown that the decreased tumorigenicity of FReP cells was directly related to an upregulation of cyclin-dependent kinase inhibitor 2B (CDKN2B) expression during the FMOD reprograming process.
Fibromodulin reprogrammed cells: A novel cell source for bone regeneration.
- BiologyBiomaterials
- 2016
Generation of pluripotent stem cells without the use of genetic material
- BiologyLaboratory Investigation
- 2015
What types of small chemical or large (protein) molecules could be used to replace the viral transduction of genes and/or genetic reprogramming to obtain human iPSCs are discussed.
Brief Azacytidine Step Allows The Conversion of Suspension Human Fibroblasts into Neural Progenitor-Like Cells
- BiologyCell journal
- 2015
This work provides a simple way to induce neural progenitor-like cells from human fibroblasts without genetic manipulation by changing physicochemical culture properties from monolayer culture into a suspension in the presence of a chemical DNA methyltransferase inhibitor agent, Azacytidine.
Targeting cell plasticity for regeneration: from in vitro to in vivo reprogramming.
- BiologyAdvanced drug delivery reviews
- 2020
Pluripotency maintenance of amniotic fluid-derived stem cells cultured on biomaterials.
- Biology, EngineeringJournal of materials chemistry. B
- 2015
Surprisingly, hAFSCs that showed higher pluripotency on PVA hydrogels grafted with oligopeptides derived from fibronectin and vitronECTin also expressed higher levels of early differentiation markers for three germ layers in expansion medium, suggesting that hAF SCs are heterogeneous and that this population contains highly pluripotent stem cells and stem cells that can be easily differentiated.
Current Methods for Inducing Pluripotency in Somatic Cells
- BiologyAdvanced materials
- 2013
An overview on current reprogramming protocols is provided, discusses their pros and cons and future challenges to provide safe and transgene‐free iPSCs.
Generation of pluripotent stem cells via protein transduction.
- BiologyThe International journal of developmental biology
- 2014
An overview of the key processes and mechanism involved in protein-based somatic cell reprogramming is provided, and some promising methods for increasing its efficiency and future challenges are discussed.
Photopolymerizable hydrogel encapsulated fibromodulin-reprogrammed cells for muscle regeneration.
- Biology, EngineeringTissue engineering. Part A
- 2020
The photopolymerizable methacrylate glycol chitosan (MeGC)/type I collagen (ColI)-hydrogel provides a desirable microenvironment for encapsulated FReP cells survival, spreading, extension, and formation of myotubes in the hydrogel three-dimensionally in vitro, without undesired osteogenic, chondrogenic, or tenogenic differentiation.
Cardiomyocyte generation from somatic sources - current status and future directions.
- BiologyCurrent opinion in biotechnology
- 2016
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