Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response.

  title={Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response.},
  author={Vanessa E. Zannella and Alan Dal Pra and Hala Muaddi and Trevor McKee and Shawn Stapleton and Jenna R Sykes and Rachel Glicksman and Selim Chaib and Paul Zamiara and Michael F. Milosevic and Bradly G. Wouters and Robert G. Bristow and Marianne Koritzinsky},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={19 24},
PURPOSE Tumor hypoxia is a negative prognostic factor in multiple cancers, due in part to its role in causing resistance to radiotherapy. Hypoxia arises in tumor regions distal to blood vessels as oxygen is consumed by more proximal tumor cells. Reducing the rate of oxygen consumption is therefore a potential strategy to reduce tumor hypoxia. We hypothesized that the anti-diabetic drug metformin, which reduces oxygen consumption through inhibition of mitochondrial complex I, would improve… CONTINUE READING
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