Reprogramming in vivo produces teratomas and iPS cells with totipotency features

  title={Reprogramming in vivo produces teratomas and iPS cells with totipotency features},
  author={Mar{\'i}a Abad and Lluc Mosteiro and Cristina Pantoja and Marta Ca{\~n}amero and Teresa Rayon and Inmaculada Ors and Osvaldo Gra{\~n}a and Diego Meg{\'i}as and Orlando Dom{\'i}nguez and Dolores Mart{\'i}nez and Miguel Manzanares and Sagrario Ortega and Manuel Serrano},
Reprogramming of adult cells to generate induced pluripotent stem cells (iPS cells) has opened new therapeutic opportunities; however, little is known about the possibility of in vivo reprogramming within tissues. Here we show that transitory induction of the four factors Oct4, Sox2, Klf4 and c-Myc in mice results in teratomas emerging from multiple organs, implying that full reprogramming can occur in vivo. Analyses of the stomach, intestine, pancreas and kidney reveal groups of… 

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