Reprogramming fibroblasts into bipotential hepatic stem cells by defined factors.

  title={Reprogramming fibroblasts into bipotential hepatic stem cells by defined factors.},
  author={Bing Yu and Zhiying He and P F You and Qing-wang Han and Dao Xiang and Fei Chen and Min-jun Wang and Chang-Cheng Liu and Xi-Wen Lin and Uyunbilig Borjigin and X Zi and Jian-Xiu Li and Hai-Ying Zhu and Wen-lin Li and Chun-Sheng Han and Kirk J Wangensteen and Yufang Shi and L Hui and Xin Wang and Yi-Ping Hu},
  journal={Cell stem cell},
  volume={13 3},
Recent studies have demonstrated direct reprogramming of fibroblasts into a range of somatic cell types, but to date stem or progenitor cells have only been reprogrammed for the blood and neuronal lineages. We previously reported generation of induced hepatocyte-like (iHep) cells by transduction of Gata4, Hnf1α, and Foxa3 in p19 Arf null mouse embryonic fibroblasts (MEFs). Here, we show that Hnf1β and Foxa3, liver organogenesis transcription factors, are sufficient to reprogram MEFs into… CONTINUE READING
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Direct reprogramming of fibroblasts into neural stemcells bydefined factors.Cell StemCell10, 465–472

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