Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis.

@article{Georgoudaki2016ReprogrammingTM,
  title={Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis.},
  author={Anna-Maria Georgoudaki and Kajsa E Prokopec and Vanessa F. Boura and Eva Kjellander Hellqvist and Silke Sohn and Jeanette {\"O}stling and Rony Dahan and Robert A. Harris and Mattias Rantalainen and Daniel Klevebring and Malin Sund and Suzanne Egyh{\'a}zi Brage and Jonas Fuxe and Charlotte Rolny and Fubin Li and Jeffrey V Ravetch and Mikael C I Karlsson},
  journal={Cell reports},
  year={2016},
  volume={15 9},
  pages={
          2000-11
        }
}
Tumors are composed of multiple cell types besides the tumor cells themselves, including innate immune cells such as macrophages. Tumor-associated macrophages (TAMs) are a heterogeneous population of myeloid cells present in the tumor microenvironment (TME). Here, they contribute to immunosuppression, enabling the establishment and persistence of solid tumors as well as metastatic dissemination. We have found that the pattern recognition scavenger receptor MARCO defines a subtype of suppressive… CONTINUE READING
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