Reprogramming Primordial Germ Cells into Pluripotent Stem Cells

  title={Reprogramming Primordial Germ Cells into Pluripotent Stem Cells},
  author={Gabriela Durcova-Hills and Fuchou Tang and Gina M Doody and Reuben M Tooze and M. Azim Surani},
  journal={PLoS ONE},
  pages={207 - 213}
BACKGROUND Specification of primordial germ cells (PGCs) results in the conversion of pluripotent epiblast cells into monopotent germ cell lineage. Blimp1/Prmt5 complex plays a critical role in the specification and maintenance of the early germ cell lineage. However, PGCs can be induced to dedifferentiate back to a pluripotent state as embryonic germ (EG) cells when exposed to exogenous signaling molecules, FGF-2, LIF and SCF. METHODOLOGY AND PRINCIPAL FINDINGS Here we show that Trichostatin… CONTINUE READING
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Isolation and maintenance of murine embryonic germ cell lines

  • G Durcova-Hills, McLaren
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