Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded

  title={Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded},
  author={Roberto B Cattaneo and Tanner S. Miest and Elena V. Shashkova and Michael Anthony Barry},
  journal={Nature Reviews Microbiology},
Virotherapy is currently undergoing a renaissance, based on our improved understanding of virus biology and genetics and our better knowledge of many different types of cancer. Viruses can be reprogrammed into oncolytic vectors by combining three types of modification: targeting, arming and shielding. Targeting introduces multiple layers of cancer specificity and improves safety and efficacy; arming occurs through the expression of prodrug convertases and cytokines; and coating with polymers… CONTINUE READING
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