Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages.

@article{SchenkeLayland2008ReprogrammedMF,
  title={Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages.},
  author={Katja Schenke-Layland and Katrin E. Rhodes and Ekaterini Angelis and Yekaterina Butylkova and Sepideh Heydarkhan-Hagvall and Christos Gekas and Rui Xiang Zhang and Joshua I. Goldhaber and Hanna K. A. Mikkola and Kathrin Plath and W. Robb MacLellan},
  journal={Stem cells},
  year={2008},
  volume={26 6},
  pages={
          1537-46
        }
}
Forced expression of the four transcription factors Oct4, Sox2, c-Myc, and Klf4 is sufficient to confer a pluripotent state upon the murine fibroblast genome, generating induced pluripotent stem (iPS) cells. Although the differentiation potential of these cells is thought to be equivalent to that of embryonic stem (ES) cells, it has not been rigorously determined. In this study, we sought to identify the capacity of iPS cells to differentiate into Flk1-positive progenitors and their mesodermal… CONTINUE READING

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