Reprofiling a classical anthelmintic, pyrvinium pamoate, as an anti-cancer drug targeting mitochondrial respiration

Abstract

Pyrvinium pamoate (PP) is an FDA-approved classical anthelmintic, but is now attracting particular attention as an anti-cancer drug after recent findings of its potent cytotoxicity against various cancer cell lines only during glucose starvation, as well as its anti-tumor activity against hypovascular pancreatic cancer cells transplanted in mice. The… (More)
DOI: 10.3389/fonc.2012.00137

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@inproceedings{Ishii2012ReprofilingAC, title={Reprofiling a classical anthelmintic, pyrvinium pamoate, as an anti-cancer drug targeting mitochondrial respiration}, author={Isao Ishii and Yasuo Harada and Tadashi Kasahara}, booktitle={Front. Oncol.}, year={2012} }