Reproductive toxicity of low level bisphenol A exposures in a two-generation zebrafish assay: Evidence of male-specific effects.

@article{Chen2015ReproductiveTO,
  title={Reproductive toxicity of low level bisphenol A exposures in a two-generation zebrafish assay: Evidence of male-specific effects.},
  author={Jiangfei Chen and Yanyan Xiao and Zengxin Gai and Rong Li and Zixu Zhu and Chenglian Bai and Robert L. Tanguay and Xiaojiang Xu and Changjiang Huang and Qiaoxiang Dong},
  journal={Aquatic toxicology},
  year={2015},
  volume={169},
  pages={204-14}
}
Bisphenol A (BPA), a high-volume chemical used to make polycarbonate plastic and epoxy resins, is a ubiquitous contaminant in environment and human body. To investigate the reproductive effects of long-term exposure to low concentrations of BPA, a two-generation study was conducted using the aquatic model species of zebrafish. Our findings revealed that exposure to 1nM (0.228μg/L) BPA for continuous two generations resulted in female-biased sex ratio in both F1 and F2 adult population… CONTINUE READING
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