Reproductive toxicity of lapachol in adult male Wistar rats submitted to short-term treatment.

@article{S2007ReproductiveTO,
  title={Reproductive toxicity of lapachol in adult male Wistar rats submitted to short-term treatment.},
  author={Rita de C{\'a}ssia da Silveira e S{\'a} and Martha de Oliveira Guerra},
  journal={Phytotherapy research : PTR},
  year={2007},
  volume={21 7},
  pages={658-62}
}
Lapachol is a therapeutic naphthoquinone, but little is known about its general and reproductive toxicity. In female rats, a high incidence of resorptions and fetal mortality has been reported. This work analyses the effect of the short-term administration of lapachol on vital and reproductive organs, and sperm production in Wistar rats. Adult animals were treated with 1 mL of lapachol hydroalcohol solution (100 mg/kg of body weight) for 5 days and killed 3 (T1) and 14 days (T2) after the end… CONTINUE READING
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