Reproductive technologies and the risk of birth defects.

@article{Davies2012ReproductiveTA,
  title={Reproductive technologies and the risk of birth defects.},
  author={M. Davies and V. Moore and K. Willson and Phillipa van Essen and K. Priest and H. Scott and E. Haan and A. Chan},
  journal={The New England journal of medicine},
  year={2012},
  volume={366 19},
  pages={
          1803-13
        }
}
BACKGROUND The extent to which birth defects after infertility treatment may be explained by underlying parental factors is uncertain. METHODS We linked a census of treatment with assisted reproductive technology in South Australia to a registry of births and terminations with a gestation period of at least 20 weeks or a birth weight of at least 400 g and registries of birth defects (including cerebral palsy and terminations for defects at any gestational period). We compared risks of birth… Expand
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References

SHOWING 1-10 OF 38 REFERENCES
Risk of birth defects increased in pregnancies conceived by assisted human reproduction.
TLDR
There is a significant increased risk of birth defects associated with AHR, and the risk is higher in IVF and IUI than in the non-AHR population. Expand
Assisted reproductive technology and major structural birth defects in the United States.
TLDR
Findings suggest that some birth defects occur more often among infants conceived with ART, and couples considering ART should be informed of all potential risks and benefits. Expand
Safety issues in assisted reproductive technology: aetiology of health problems in singleton ART babies.
TLDR
The analysis of the outcome of singleton pregnancies resulting from IVF versus artificial insemination, obtained with or without the use of ovarian stimulatory agents, suggests that female infertility is an important risk factor. Expand
Increased risk of blastogenesis birth defects, arising in the first 4 weeks of pregnancy, after assisted reproductive technologies.
TLDR
There is a specific risk of blastogenesis birth defects arising very early in pregnancy after IVF or ICSI and that this risk may be lower with use of frozen-thawed embryo transfer. Expand
Infertility, infertility treatment, and congenital malformations: Danish national birth cohort
TLDR
The results suggest that the reported increased prevalence of congenital malformations seen in singletons born after assisted reproductive technology is partly due to the underlying infertility or its determinants. Expand
The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization
TLDR
Findings support the possibility of an excessive risk of major birth defects in infants born with the benefit of assisted reproductive technology and caution is in order when establishing associations with particular birth defects. Expand
The risk of birth defects in children born after assisted reproductive technologies
TLDR
Current evidence suggests there is an elevated risk of birth defects in children born following assisted reproductive technologies, and one certainly cannot exclude this possibility on the basis of the current evidence. Expand
Are Children Born After Assisted Reproductive Technology at Increased Risk for Adverse Health Outcomes?
TLDR
There is evidence of an increase in chromosomal abnormalities among pregnancies conceived using intracytoplasmic sperm injection and low birth weight and preterm delivery among singletons conceived with all types of ART; however, there remains uncertainty about whether these risks stem from the treatment or the parental infertility. Expand
Assisted reproductive technologies and the risk of birth defects--a systematic review.
TLDR
Pooled results from all suitable published studies suggest that children born following ART are at increased risk of birth defects compared with spontaneous conceptions. Expand
Birth defects in children conceived by ICSI compared with children conceived by other IVF-methods; a meta-analysis.
TLDR
The analysis does not indicate that the ICSI-procedure represents significant additional risks of major birth defects in addition to the risk involved in standard IVF, and data was limited, particularly on risks of specific categories of defects. Expand
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