Reproductive system: aromatase and estrogens

  title={Reproductive system: aromatase and estrogens},
  author={Serge Carreau and Sonia Bourguiba and Sophie Lambard and Isabelle Galeraud-Denis and J{\'e}r{\^o}me Levallet},
  journal={Molecular and Cellular Endocrinology},
The cytochrome P450 aromatase (P450arom) is the terminal enzyme responsible for the formation of estrogens from androgens. In the rat testis we have immunolocalized the P450arom not only in Leydig cells but also in germ cells and especially in elongated spermatids. Related to the stage of germ cell maturation, we have shown that the level of P450arom transcripts decreases, it is much more abundant in pachytene spermatocytes (PS) than in mature germ cells whereas the aromatase activity is two… CONTINUE READING


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