Reproductive immunology: Immunity's pregnant pause

@article{Pearson2002ReproductiveII,
  title={Reproductive immunology: Immunity's pregnant pause},
  author={Helen R. Pearson},
  journal={Nature},
  year={2002},
  volume={420},
  pages={265-266}
}
  • H. Pearson
  • Published 21 November 2002
  • Medicine
  • Nature
If we can understand why a woman's body does not reject her fetus, it could help us to treat infertility and prevent problems in pregnancy. Helen Pearson reports. 
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64 Citations
Background Citations
19
Results Citations
1

64 Citations

IL-10, HLA-G and Neutrophil Extracellular Traps as Immune Regulators in Recurrent Pregnancy Loss
  • M. Monti
  • Medicine, Biology
    Biomedical Journal of Scientific & Technical Research
  • 2020
TLDR
Recurrent pregnancy loss is a main reproductive health issue and there are several known causes such as endocrine-related miscarriages, but the causes are still poorly understood.
Clinical presentations and outcomes of SARS-CoV-2 infected pneumonia in pregnant women and health status of their neonates
The Skewed TCR‐BV Repertoire Displayed at the Maternal–Fetal Interface of Women with Unexplained Pregnancy Loss
The study was undertaken to investigate T‐cell receptor (TCR) variable β (BV)‐chain usage at maternal–fetal interface and explore the relationship between the skewed TCR‐BV usage and unexplained…
Mouse model for allogeneic immune reaction against fetus recapitulates human pre‐eclampsia
TLDR
It is hypothesized that induction of maternal allogeneic immune reaction by reduced IDO activity is one of the causes of pre‐eclampsia.
Regulatory T cells mediate maternal tolerance to the fetus
TLDR
An alloantigen-independent, systemic expansion of the maternal CD25+ T cell pool during pregnancy is demonstrated and it is shown that this population contains dominant regulatory T cell activity.
Mother's little helpers: mechanisms of maternal-fetal tolerance
TLDR
During pregnancy, the semi-allogeneic fetus is protected from assault by the maternal immune system over an extended period of time, and the mother's immune system seems to recognize the fetus as 'temporary self'.
Intralipid therapy for recurrent implantation failure: new hope or false dawn?
Overproduction of the follistatin‐related gene protein in the placenta and maternal serum of women with pre‐eclampsia
Objective  To characterise the follistatin‐related gene (FLRG) in pre‐eclampsia, one of the differentially expressed genes in pre‐eclamptic placenta.
Natural Killer cells: Keepers of pregnancy in the turnstile of the environment
The up side of decidual natural killer cells: new developments in immunology of pregnancy
TLDR
The new data demonstrate that dNK cells undergo fine tuning or even subvert their classical inhibitory machinery and turn into a real defence force in order to prevent the spread of viruses to fetal tissue.
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