Reproductive immunology: Immunity's pregnant pause

  title={Reproductive immunology: Immunity's pregnant pause},
  author={Helen R. Pearson},
  • H. Pearson
  • Published 21 November 2002
  • Medicine
  • Nature
If we can understand why a woman's body does not reject her fetus, it could help us to treat infertility and prevent problems in pregnancy. Helen Pearson reports. 
IL-10, HLA-G and Neutrophil Extracellular Traps as Immune Regulators in Recurrent Pregnancy Loss
  • M. Monti
  • Medicine, Biology
    Biomedical Journal of Scientific & Technical Research
  • 2020
Recurrent pregnancy loss is a main reproductive health issue and there are several known causes such as endocrine-related miscarriages, but the causes are still poorly understood.
The Skewed TCR‐BV Repertoire Displayed at the Maternal–Fetal Interface of Women with Unexplained Pregnancy Loss
The study was undertaken to investigate T‐cell receptor (TCR) variable β (BV)‐chain usage at maternal–fetal interface and explore the relationship between the skewed TCR‐BV usage and unexplained
Mouse model for allogeneic immune reaction against fetus recapitulates human pre‐eclampsia
It is hypothesized that induction of maternal allogeneic immune reaction by reduced IDO activity is one of the causes of pre‐eclampsia.
Regulatory T cells mediate maternal tolerance to the fetus
An alloantigen-independent, systemic expansion of the maternal CD25+ T cell pool during pregnancy is demonstrated and it is shown that this population contains dominant regulatory T cell activity.
Mother's little helpers: mechanisms of maternal-fetal tolerance
During pregnancy, the semi-allogeneic fetus is protected from assault by the maternal immune system over an extended period of time, and the mother's immune system seems to recognize the fetus as 'temporary self'.
Overproduction of the follistatin‐related gene protein in the placenta and maternal serum of women with pre‐eclampsia
Objective  To characterise the follistatin‐related gene (FLRG) in pre‐eclampsia, one of the differentially expressed genes in pre‐eclamptic placenta.
Natural Killer cells: Keepers of pregnancy in the turnstile of the environment
The up side of decidual natural killer cells: new developments in immunology of pregnancy
The new data demonstrate that dNK cells undergo fine tuning or even subvert their classical inhibitory machinery and turn into a real defence force in order to prevent the spread of viruses to fetal tissue.


Natural killer cells and pregnancy
No convincing evidence of uterine maternal T-cell recognition of placental trophoblast cells has been found, but instead, there might be maternal allorecognition mediated by uterine natural killer cells that recognize unusual fetal trophOBlast MHC ligands.
Prevention of allogeneic fetal rejection by tryptophan catabolism.
In 1953 Medawar pointed out that survival of the genetically disparate (allogeneic) mammalian conceptus contradicts the laws of tissue transplantation and suppresses T cell activity and defends itself against rejection.
The effect of intercourse on pregnancy rates during assisted human reproduction.
Exposure to semen around the time of embryo transfer increases the likelihood of successful early embryo implantation and development.
A critical role for murine complement regulator crry in fetomaternal tolerance.
The regulation of complement is critical in fetal control of maternal processes that mediate tissue damage and survival of Crry-/- embryos was compromised because of complement deposition and concomitant placenta inflammation.
Prevention of T cell–driven complement activation and inflammation by tryptophan catabolism during pregnancy
Indoleamine 2,3 dioxygenase activity during pregnancy protects developing fetuses from maternal immune responses in CBA mice by suppressing T cell–driven local inflammatory responses to fetal alloantigens.
HLA‐G expression in early embryos is a fundamental prerequisite for the obtainment of pregnancy
Investigation of the presence of sHLA‐G molecules in culture supernatants of early embryos obtained by in vitro fertilization (IVF) before transfer indicates that expression of HLA‐G products in embryo cells is a mandatory, but not sufficient, prerequisite for the development of pregnancy.
Corticotropin-releasing hormone promotes blastocyst implantation and early maternal tolerance
It is suggested that locally produced CRH promotes implantation and maintenance of early pregnancy primarily by killing activated T cells.
Cutting Edge: Soluble HLA-G1 Triggers CD95/CD95 Ligand-Mediated Apoptosis in Activated CD8+ Cells by Interacting with CD81
It is shown that sHLA-G1-induced apoptosis depends on the interaction with CD8 molecules, with cell death being blocked by various CD8 mAbs, and that apoptosis is mediated through the CD95/CD95 ligand pathway.