Reproductive hormones regulate the selective permeability of the blood-brain barrier.

@article{Wilson2008ReproductiveHR,
  title={Reproductive hormones regulate the selective permeability of the blood-brain barrier.},
  author={Andrea C. Wilson and Luca Clemente and Tianbing Liu and Richard L. Bowen and Sivan Vadakkadath Meethal and Craig S Atwood},
  journal={Biochimica et biophysica acta},
  year={2008},
  volume={1782 6},
  pages={401-7}
}
Reproductive hormones have been demonstrated to modulate both gap and tight junction protein expression in the ovary and other reproductive tissues, however the effects of changes in reproductive hormones on the selective permeability of the blood-brain barrier (BBB) remain unclear. Age-related declines in BBB integrity correlate with the loss of serum sex steroids and increase in gonadotropins with menopause/andropause. To examine the effect of reproductive senescence on BBB permeability and… CONTINUE READING