Reproductive function in male patients with type 1 diabetes mellitus

  title={Reproductive function in male patients with type 1 diabetes mellitus},
  author={Sandro La Vignera and R A Condorelli and Maurizio Di Mauro and Donatella Lo Presti and Laura Maria Mongio{\`i} and Giorgio Ivan Russo and Aldo Eugenio Calogero},
This study was undertaken to evaluate conventional and some of the main bio‐functional spermatozoa parameters, serum gonadal hormones and didymo‐epididymal ultrasound features in patients with type 1 diabetes mellitus (DM1). DM1 affects an increasing number of men of reproductive age. Diabetes may affect male reproduction by acting on the hypothalamic–pituitary–testicular axis, causing sexual dysfunction or disrupting male accessory gland function. However, data on spermatozoa parameters and… 

Effects of Diabetes Mellitus type 2 on Semen Parameters

Introduction: Diabetes Mellitus (DM) is a chronic metabolic disease that affects all the physiological systems of the body and recently, the age of suffering from DM has decreased. The aim of this

The impact of type 1 diabetes mellitus on male sexual functions and sex hormone levels.

Significant changes in sexual functions and sex hormone blood concentrations that indicate impairment of sexual and reproductive functions in T1DM males are found.

Antidiabetic therapies and male reproductive function: where do we stand?

Much is still to be determined and further studies are needed to clarify the safety of these antidiabetic strategies on male reproductive system, aspects such as the effects of insulin levels variations, consequent of insulin therapy, as well as what will be the impact of the side effect hypoglycemia, common to several therapeutic strategies discussed, on themale reproductive system are still to been addressed.

Can antidiabetic drugs improve male reproductive (dys)function associated with diabetes?

A critical assessment of the literature on the effects of several antidiabetic drugs on male reproductive function is made, finding there is an abundance of controversial reports related to the various study designs, experimental models and compounds used.

Ejaculatory dysfunction in men with diabetes mellitus

Although both diabetes patients and their physicians are increasingly aware of diabetic ejaculatory dysfunction, this awareness still lags behind that of other diabetes complications.

Effects of diabetes mellitus on semen quality in adult men : a systematic review and meta-analysis

The study indicated that DM had negative effects on semen quality, and sperm DNA fragmentation was significantly higher in DM patients than in nondiabetic controls.

Effects of Colostrum on Sperm Parameters, Sex Hormones and Testes Histopathological Changes in Diabetic Rats

Evidence is provided that CLO treatment can inhibit the progression of reproductive system complication in diabetic rats, and the COL treated rats showed an improved histologic appearance and serum testosterone levels.

Studies on male gonadal toxicity of bisphenol A in diabetic rats: An example of exacerbation effect

The present study confirmed that BPA exposure in DIA conditions exacerbated the testicular damages in SD rats, and the DIA condition might have increased male gonadal toxicity due to BPA Exposure and requires further attention to maintain their normal reproductive health.

Risk factors on testicular function in adolescents

Evidence collected seems to suggest that andrological health in adolescence may be impaired by several factors, as varicocele, cryptorchidism, and childhood cancer, which might contribute to impair reproductive health, but more studies in adolescents are needed.



Insulin dependant diabetes mellitus: implications for male reproductive function.

Diabetes is associated with increased sperm nuclear and mtDNA damage that may impair the reproductive capability of men attending fertility clinics and this work aims to address this concern.

Semen analysis in insulin-dependent/non-insulin-dependent diabetic men with/without neuropathy.

A significant rise in total sperm output in both IDDM and NIDDM neuropathic diabetic patients and a significant decrease in semen volume in both types of diabetic patients thus suggests some kind of Leydig cell hyperplasia, which in turn may stimulate spermatogenesis and atonia of the bladder and urethra, resulting in retrograde ejaculation.

A Study of Spermatozoal Motility in Type 1 Diabetes Mellitus

It is concluded that diabetic men, in the absence of complications, do not appear to be at a disadvantage in terms of sperm motility compared to healthy individuals.

Diabetes mellitus and sperm parameters.

The main sperm parameters in patients with diabetes mellitus are shown and the mechanisms hypothesized to explain the changes observed in these patients are presented.

Semen analyses in adolescent diabetic patients

A deterioration of the quality of human semen occurs in adolescent diabetic patients and Neuropathy and poor metabolic control seem to be important factors of this deterioration.

Neurophysiological role of sildenafil citrate (Viagra) on seminal parameters in diabetic males with and without neuropathy.

A chronic neuro physiological effect of sildenafil treatment on male fertility profile exclusively in diabetic neuropathic condition with an improvement in testicular function which was probably arrested due to some kind of testicular hyperplasia resulted by testicular necrosis and promoted spermatogenesis is suggested.

Distribution of the receptor for advanced glycation end products in the human male reproductive tract: prevalence in men with diabetes mellitus.

The presence of RAGE implies that it may play a central role in sperm nDNA damage particularly in diabetic men where the levels are elevated.

A practical guide to male hypogonadism in the primary care setting

Testosterone treatment is contraindicated in subjects with prostate cancer or benign prostate hyperplasia and risks of treatment are perceived to be high by many physicians, however, these risks are often exaggerated and should not outweigh the benefits of testosterone treatment.

Clinical, immunological, and genetic heterogeneity of diabetes in an Italian population-based cohort of lean newly diagnosed patients aged 30-54 years. Piedmont Study Group for Diabetes Epidemiology.

Almost 50% of lean young and middle-aged patients were ICA+ and/or anti-GAD+, suggesting a high prevalence of a slowly evolving form of type 1 diabetes.

Fertility in people with childhood-onset type 1 diabetes

Type 1 diabetes affects the number of live births in both women and men, and the age at onset of diabetes is associated with the pattern of reproduction in both diabetic women andMen.