Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor.

@article{Tilley1999ReproductiveFA,
  title={Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor.},
  author={Stephen L. Tilley and Laurent P. Audoly and Erin Hicks and Hyun Soo Kim and Patrick J. Flannery and Thomas M. Coffman and Beverly H. Koller},
  journal={The Journal of clinical investigation},
  year={1999},
  volume={103 11},
  pages={1539-45}
}
Prostaglandins (PGs) are bioactive lipids that modulate a broad spectrum of biologic processes including reproduction and circulatory homeostasis. Although reproductive functions of mammals are influenced by PGs at numerous levels, including ovulation, fertilization, implantation, and decidualization, it is not clear which PGs are involved and whether a single mechanism affects all reproductive functions. Using mice deficient in 1 of 4 prostaglandin E2 (PGE2) receptors -- specifically, the EP2… CONTINUE READING