Reproductive factors, oral contraceptive use, and risk of colorectal cancer.

  title={Reproductive factors, oral contraceptive use, and risk of colorectal cancer.},
  author={Rebecca Troisi and Catherine Schairer and W-H. Chow and Arthur S Schatzkin and Louise A Brinton and Joseph F. Jr. Fraumeni},
  volume={8 1},
Multiparity and use of oral contraceptives are hypothesized to reduce risk of colorectal cancer. Among 57,529 women, 31-90 years of age, who volunteered for a nationwide breast cancer screening program from 1973 to 1980, we observed 154 pathologically confirmed cases of colon cancer and 49 cases of rectal cancer in up to 10 years of follow-up (388,555 person-years). Parity was not associated with risk of colorectal cancer [age-adjusted rate ratio for > or = 4 children vs no children = 1.0; 95… CONTINUE READING


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