Reproductive endocrine issues in men with sickle cell anemia

  title={Reproductive endocrine issues in men with sickle cell anemia},
  author={A W Huang and Ozgul Muneyyirci-Delale},
In patients with sickle cell anemia, the sickling of red blood cells is known to cause end‐organ damage by infarction. In some men who are affected by sickle cell anemia, the obstruction of venous outflow of the penis causes priapism, which could lead to erectile dysfunction. There is also evidence that the disease is linked to other reproductive issues in men—specifically delayed puberty, low testosterone, and sperm abnormalities—although the causes of these problems are less clear. Treatment… 

Testosterone Deficiency in Sickle Cell Disease: Recognition and Remediation

A novel approach is to target the mechanisms of testosterone deficiency in the SCD testis to drive endogenous testosterone production, which potentially decreases further oxidative stress and damage in the testis, and preserves sperm quality.

Advances in the Treatment of Sickle Cell Disease

Compensated hypogonadism in men with sickle cell disease

To evaluate the prevalence of hypogonadism in a population of men with SCD and characterize its aetiology, a large number of patients withSCD were diagnosed with atypical EMTs.

Testicular Volume in Children with Sickle Cell Anaemia in Uyo, a South-South Nigerian City.

The frequency of testicular pain, weight and pubic hair stage of the SCA boys were important contributors to their increased testes sizes, irrespective of pubertal status, and independent predictors of TV changes in the HbSS participants.

The Effect of Serum Ferritin Level on Gonadal, Prolactin, Thyroid Hormones, and Thyroid Stimulating Hormone in Adult Males with Sickle Cell Anemia

Adult males with SCD with high serum ferritin level were shorter than adult males withSCD who had normal serum ferrisin level and had a significant lower level of serum testosterone and significant high level of LH and this was most likely due to endocrine dysfunction secondary to high ferrit in level and iron overload.

Epidemiology of Male Hypogonadism.

Serum testosterone level and semen quality in male patients with sickle cell disease in outpatient department of Chhattisgarh: a case-control study.

Men in Chhattisgarh with SCD do not suffer from any reproductive disorders such as delayed sexual maturity, low serum testosterone, poor semen quality, or hypogonadism.

Sexual health of French adolescents with sickle cell disease

  • Marion GrosC. Jung Adèle Carlier-Gonod
  • Medicine, Psychology
    The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
  • 2020
Clinicians caring for teenagers followed for SCD should be aware of the need for sexual health information in order to propose prevention actions adapted to these young people with chronic disease.

Fertility testing knowledge and attitudes in male adolescents and young adults with SCD and their caregivers: a pilot study

Early diagnosis and effective use of disease-modifying and curative therapies have resulted in $ 93% of youth with sickle cell disease (SCD) living into adulthood with less disease morbidity. 1

Mechanisms underlying priapism in sickle cell disease: targeting and key innovations on the preclinical landscape

The consequences of downregulated cGMP-dependent phosphodiesterase type 5 (PDE5) activity in response to these molecular signaling derangements, as the main effector mechanism causing unrestrained cavernous tissue relaxation that results in priapism are discussed.



Gonadal function abnormalities in sickle cell anemia. Studies in adult male patients.

It is shown that androgen deficiency in this disease is a result of primary rather than secondary hypogondadism, and the role of zinc in the pathogenesis of testicular failure in sickle cell anemia is established.

Testicular dysfunction in men with sickle cell disease.

The tendency for higher gonadotrophins associated with lower testosterone in subjects with SCD suggests that the hypothalamic/pituitary function in these patients is intact and that the primary fault leading to poor sperm production lies in the testes.

Fertility studies in sickle cell disease: semen analysis in adult male patients.

Findings show that there are definite abnormalities associated with semen in sickle cell anemia and suggest that in addition to testicular dysfunction, there may be abnormalities in the accessory sex organs, such as the seminal vesicles and the prostate gland, particularly in view of the marked decrease in ejaculate volume of the patients.

Effect of hydroxyurea on sperm count, motility and morphology in adult men with sickle cell or myeloproliferative disease

  • A. Grigg
  • Medicine, Biology
    Internal medicine journal
  • 2007
A retrospective review of four adult men who had semen analysis during HU therapy and in three cases after its cessation suggests that HU generally reduces sperm counts and motility and results in abnormal morphology.

Vascular occlusion and infarction in sickle cell crisis and the sickle chest syndrome.

A young adult with homozygous sickle cell anaemia (Hb SS) suffered a fatal sickle cell crisis complicated by the sickle chest syndrome. At necropsy multiple large infarcts of the lung, bone marrow,

Genitourinary complications of sickle cell disease.

Hypogonadism in Patients with Sickle Cell Disease: Central or Peripheral?

A cross-sectional study to determine whether hypogonadism in male patients with SCD is due to primary testicular failure or secondary pituitary/hypothalamic dysfunction and assess the association between hypog onadism and serum ferritin levels indicates a central etiology.