Reproductive and developmental toxicity studies of manufactured nanomaterials.

  title={Reproductive and developmental toxicity studies of manufactured nanomaterials.},
  author={Makoto Ema and Norihiro Kobayashi and Masato Naya and Sosuke Hanai and Junko Nakanishi},
  journal={Reproductive toxicology},
  volume={30 3},
This paper reviews studies in vivo and in vitro on the reproductive and developmental toxicity of manufactured nanomaterials including metallic and metal oxide-based particles, fullerenes (C(60)), carbon black (CB), and luminescent particles. Studies in vivo showed increased allergic susceptibility in offspring of mouse dams intranasally insufflated with respirable-size titanium dioxide (TiO(2)), adverse effects on spermatogenesis and histopathological changes in the testes and changes in gene… CONTINUE READING