Reproductive and Developmental Toxicity of Phthalates
@article{Lyche2009ReproductiveAD, title={Reproductive and Developmental Toxicity of Phthalates}, author={J. Lyche and A. Gutleb and {\AA}. Bergman and G. Eriksen and A. Murk and E. Ropstad and M. Saunders and J. U. Skaare}, journal={Journal of Toxicology and Environmental Health, Part B}, year={2009}, volume={12}, pages={225 - 249} }
The purposes of this review are to (1) evaluate human and experimental evidence for adverse effects on reproduction and development in humans, produced by exposure to phthalates, and (2) identify knowledge gaps as for future studies. The widespread use of phthalates in consumer products leads to ubiquitous and constant exposure of humans to these chemicals. Phthalates were postulated to produce endocrine-disrupting effects in rodents, where fetal exposure to these compounds was found to induce… CONTINUE READING
Topics from this paper
Paper Mentions
370 Citations
The effects of phthalates in the cardiovascular and reproductive systems: A review.
- Medicine
- Environment international
- 2016
- 90
Developmental neurotoxicity of ortho-phthalate diesters: review of human and experimental evidence.
- Medicine
- Neurotoxicology
- 2014
- 90
Di-(2-ethylhexyl) Phthalate (DEHP) and Uterine Histological Characteristics
- Biology, Medicine
- Development & reproduction
- 2020
- 4
- Highly Influenced
- PDF
Chronic exposure to mono-(2-ethylhexyl)-phthalate causes endocrine disruption and reproductive dysfunction in zebrafish.
- Biology, Medicine
- Environmental toxicology and chemistry
- 2016
- 16
Reproductive toxicity of di(2-ethylhexyl) phthalate in selenium-supplemented and selenium-deficient rats
- Medicine
- Drug and chemical toxicology
- 2011
- 46
- Highly Influenced
Fetal origin of endocrine dysfunction in the adult: The phthalate model
- Biology, Medicine
- The Journal of Steroid Biochemistry and Molecular Biology
- 2013
- 91
Mechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalate.
- Medicine
- Mutation research
- 2012
- 79
Metabolic, reproductive and thyroid effects of Bis(2-ethylhexyl) phthalate (DEHP) orally administered to male and female juvenile rats at dose levels derived from children biomonitoring study.
- Medicine
- Toxicology
- 2020
Assessing differences in toxicity and teratogenicity of three phthalates, Diethyl phthalate, Di-n-propyl phthalate, and Di-n-butyl phthalate, using Xenopus laevis embryos
- Biology, Medicine
- Journal of toxicology and environmental health. Part A
- 2016
- 23
References
SHOWING 1-10 OF 258 REFERENCES
Mechanisms of phthalate ester toxicity in the female reproductive system.
- Biology, Medicine
- Environmental health perspectives
- 2003
- 490
- Highly Influential
A Category Approach for Reproductive Effects of Phthalates
- Biology, Medicine
- Critical reviews in toxicology
- 2006
- 113
- Highly Influential
- PDF
Effects of phthalate esters on the developing reproductive tract of male rats
- Biology, Medicine
- Human reproduction update
- 2001
- 94
Monitoring phthalate exposure in humans.
- Chemistry, Medicine
- Clinica chimica acta; international journal of clinical chemistry
- 2005
- 324
Potential adverse effects of phthalic acid esters on human health: a review of recent studies on reproduction.
- Biology, Medicine
- Regulatory toxicology and pharmacology : RTP
- 2008
- 288
- Highly Influential
In utero exposure to phthalates and fetal development.
- Biology, Medicine
- Current medicinal chemistry
- 2006
- 52
- Highly Influential
Integrating Biomonitoring Exposure Data into the Risk Assessment Process: Phthalates [Diethyl Phthalate and Di(2-ethylhexyl) Phthalate] as a Case Study
- Chemistry, Medicine
- Environmental health perspectives
- 2006
- 158
- PDF
ESTIMATED EXPOSURE TO PHTHALATES IN COSMETICS AND RISK ASSESSMENT
- Chemistry, Medicine
- Journal of toxicology and environmental health. Part A
- 2004
- 215
- PDF