Reproductive abnormalities in female mice exposed neonatally to various doses of coumestrol.

@article{Burroughs1990ReproductiveAI,
  title={Reproductive abnormalities in female mice exposed neonatally to various doses of coumestrol.},
  author={Carol Burroughs and Kimberly Tracey Mills and Howard Alan Bern},
  journal={Journal of toxicology and environmental health},
  year={1990},
  volume={30 2},
  pages={
          105-22
        }
}
Female C57BL/Crgl mice were neonatally exposed to various doses of coumestrol to determine the threshold doses required for the occurrence of reproductive tract abnormalities. Newborn mice received daily subcutaneous injections of 10(-3), 10(-2), 8 X 10(-2), 10(-1), 1, 5, 25, 50, and 100 micrograms coumestrol in 0.005 ml dimethyl sulfoxide (DMSO) or DMSO alone, or received no treatment for the first 5 d of life. Some of the animals were ovariectomized at 40 d of age. Mice were killed at 20-22… CONTINUE READING
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