Reproduction and growth of mice and rats under conditions of simulated increased gravity.

  title={Reproduction and growth of mice and rats under conditions of simulated increased gravity.},
  author={Jiro Oyama and W. T. Platt},
  journal={The American journal of physiology},
  volume={212 1},
  • J. Oyama, W. Platt
  • Published 1967
  • Chemistry, Medicine
  • The American journal of physiology
Changes in reproduction and growth of mice and rats under chronic centrifugation at various g force conditions 
Teratogenic effects of gravitational changes.
These studies show thatDelta g is able to alter development in vivo and in vitro and suggest that delta g operates, at least in part, at the cellular level. Expand
Effects of simulated increased gravity on the rate of aging of rats: implications for the rate of living theory of aging.
Results show that a moderate increase of the level of basal metabolism of young adult rats adapted to hypergravity compared to controls in normal gravity is accompanied by a roughly similar increase in the rate of organ aging and reduction of survival, in agreement with Pearl's rate of living theory of aging, previously experimentally demonstrated only in poikilotherms. Expand
Gravity as a factor in the animal environment.
  • A. H. Smith
  • Biology, Medicine
  • Journal of animal science
  • 1972
It is expected that research involving the exposure of animals to altered gravity states will lead to new biological concepts of very broad importance. Expand
Changes in functional construction of bone in rats under conditions of simulated increased gravity
  • E. Amtmann, J. Oyama
  • Chemistry, Medicine
  • Zeitschrift für Anatomie und Entwicklungsgeschichte
  • 2004
It was shown by analysis of covariance that chronic centrifugation inhibits the longitudinal growth of the femur by the same amount as the overall growth in linear dimensions of the rat, and the alterations in cross-sectional shape of the bones in the centrifuged animals are likely due to an immobilization effect caused by centrifugations. Expand
Effect of chronic centrifugation on the structural development of the musculoskeletal system of the rat
It is shown that centrifugation has a significant effect on the relationships between cross-sectional dimensions at the mid-length of the femoral shaft and the dry weights of the triceps and of the semimembranosus muscles. Expand
Hypergravity: its effect on the estrous cycle and hormonal levels in female rats.
It was found that moderate hypergravity affects the estrous cycle by prolonging the diestrous period, and this effect seems to bear a direct relationship to the strength and timing of the hypergravity. Expand
A Body Weight Sensor Regulates Prepubertal Growth via the Somatotropic Axis in Male Rats
The gravitostat hypothesis is proposed, which states that there is a homeostatic regulation to maintain the individual specific growth channel via body weight sensing, regulating the somatotropic axis and explaining catch-up growth. Expand
Maternal Reproductive Experience Enhances Early Postnatal Outcome Following Gestation and Birth of Rats in Hypergravity1
Results indicate that repeated maternal reproductive experience affords protection against neonatal losses during exposure to increased gravity, as well as differential mortality of neonates born to primigravid versus bigravid dams. Expand
Ground-Based Researches on the Effects of Altered Gravity on Mice Development
It is shown for the first time that a transient exposure to an hypergravity environment during the period of motor development in the mouse produced an irreversible modification of the motor function. Expand


Effects of Deceleration on Rats exposed to Prolonged Centrifugation
The effects of both an increase and decrease in gravity on rats adapted to relatively high g by prolonged centrifugation are evaluated. Expand
Effects of prolonged centrifugation on growth and organ development of rats.
Results of this study show that rats are able to tolerate prolonged periods of simulated high-gravity environments with little, if any, serious deleterious effects. Expand
Effects of stimulated high altitude on the growth rate of albino guinea pigs.
Two different groups of pregnant albino guinea pigs were exposed continuously, during the second half of gestation, to simulated high altitudes of 12,000 ft in the first experiment and of 14,000–16,500ft in the second, where perinatal mortality was markedly increased. Expand