Reproducible preparation of spheroids of pancreatic hormone positive cells from human iPS cells: An in vitro study.

@article{Konagaya2016ReproduciblePO,
  title={Reproducible preparation of spheroids of pancreatic hormone positive cells from human iPS cells: An in vitro study.},
  author={Shuhei Konagaya and Hiroji Iwata},
  journal={Biochimica et biophysica acta},
  year={2016},
  volume={1860 9},
  pages={
          2008-16
        }
}
BACKGROUND Transplantation of islets of Langerhans is regarded as a promising therapy for type 1 diabetes. A large number of β-cells are required for the treatment of human type 1 diabetes. Pluripotent stem cells, such as embryonic stem cells and induced pluripotent stem cells, have been considered as new sources for cell replacement therapy. METHODS Cell aggregates were prepared from human iPS cells using agarose microwell plates and differentiated into pancreatic endocrine cells by changing… CONTINUE READING
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