Reproducible peracute glutamate-induced focal lesions of the normal rat brain using microdialysis

@article{Landolt1998ReproduciblePG,
  title={Reproducible peracute glutamate-induced focal lesions of the normal rat brain using microdialysis},
  author={Hans Landolt and Hiro Fujisawa and David I. Graham and William L Maxwell and Ross Bullock},
  journal={Journal of Clinical Neuroscience},
  year={1998},
  volume={5},
  pages={193-202}
}
The neurotoxic effect of the excitatory amino acid neurotransmitter glutamate was first demonstrated 20 years ago, but the recent development of potent glutamate antagonist drugs with effects against ischaemic damage in vivo and their introduction in clinical studies has made 'excitotoxicity' a major focus of current interest. Despite this, the factors influencing glutamate neurotoxicity in vivo are poorly understood, and the role of glutamate as a neurotoxin in vivo is contested. By using a… CONTINUE READING