Reproducibility of quantitative 18 F-3 ′-deoxy-3 ′-fluorothymidine measurements using positron emission tomography

  title={Reproducibility of quantitative 18 F-3 ′-deoxy-3 ′-fluorothymidine measurements using positron emission tomography},
  author={Adrianus J. de Langen and Bianca M. Klabbers and Mark Lubberink and Ronald Boellaard and Marieke D. Spreeuwenberg and Ben J. Slotman and Remco de Bree and Egbert F. Smit and Otto S. Hoekstra and Adriaan A. Lammertsma},
Purpose Positron emission tomography (PET) using F-3′deoxy-3′-fluorothymidine ([F]FLT) allows noninvasive monitoring of tumour proliferation. For serial imaging in individual patients, good reproducibility is essential. The purpose of the present study was to evaluate the reproducibility of quantitative [F]FLT measurements. Methods Nine patients with non-small-cell lung cancer (NSCLC) and six with head-and-neck cancer (HNC) underwent [F]FLT PET twice within 7 days prior to therapy. The maximum… CONTINUE READING


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