Reproducibility of fMRI in the clinical setting: Implications for trial designs

  title={Reproducibility of fMRI in the clinical setting: Implications for trial designs},
  author={Rose Bosnell and C. Wegner and Zsigmond Tam{\'a}s Kincses and T. Korteweg and Federica Agosta and Olga Ciccarelli and Nicola De Stefano and Achim Gass and Jochen G. Hirsch and Heidi Johansen-Berg and Ludwig Kappos and Frederik Barkhof and Laura Mancini and F. Manfredonia and S. Marino and David H. Miller and Xavier Montalban and Jackie Palace and M. Rocca and Christian Enzinger and Stefan Ropele and Alex Rovira and Stephen M. Smith and Alan J. Thompson and John S. Thornton and Tarek Yousry and Brandon J. Whitcher and Massimo Filippi and Paul M. Matthews},
With expanding potential clinical applications of functional magnetic resonance imaging (fMRI) it is important to test how reliable different measures of fMRI activation are between subjects and sessions and between centres. This study compared variability across 17 patients with multiple sclerosis (MS) and 22 age-matched healthy controls (HC) in 5 European centres performing an fMRI block design with hand tapping. We recruited subjects from sites using 1.5 T scanners from different… CONTINUE READING

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