Reproducibility of Serologic Assays for Influenza Virus A (H5N1)

  title={Reproducibility of Serologic Assays for Influenza Virus A (H5N1)},
  author={I. Stephenson and Alan M. Heath and Diane L Major and Robert W. Newman and Katja Hoschler and Wang Junzi and Jacqueline M. Katz and Jerry P Weir and Maria C. Zambon and John Wood},
  booktitle={Emerging infectious diseases},
Hemagglutination-inhibition (HI) and neutralization are used to evaluate vaccines against influenza virus A (H5N1); however, poor standardization leads to interlaboratory variation of results. A candidate antibody standard (07/150) was prepared from pooled plasma of persons given clade 1 A/Vietnam/1194/2004 vaccine. To test human and sheep antiserum, 15 laboratories used HI and neutralization and reassortant A/Vietnam/1194/2004, A/turkey/Turkey/1/2005 (clade 2.2), and A/Anhui/1/2005 (clade 2.3… CONTINUE READING

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