Reproducibility of SELDI-TOF protein patterns in serum: comparing datasets from different experiments

@article{Baggerly2004ReproducibilityOS,
  title={Reproducibility of SELDI-TOF protein patterns in serum: comparing datasets from different experiments},
  author={Keith A. Baggerly and Jeffrey S. Morris and Kevin R. Coombes},
  journal={Bioinformatics},
  year={2004},
  volume={20 5},
  pages={777-85}
}
MOTIVATION There has been much interest in using patterns derived from surface-enhanced laser desorption and ionization (SELDI) protein mass spectra from serum to differentiate samples from patients both with and without disease. Such patterns have been used without identification of the underlying proteins responsible. However, there are questions as to the stability of this procedure over multiple experiments. RESULTS We compared SELDI proteomic spectra from serum from three experiments by… CONTINUE READING
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