Reproducibility of 3D chromatin configuration reconstructions.

@article{Segal2014ReproducibilityO3,
  title={Reproducibility of 3D chromatin configuration reconstructions.},
  author={Mark R. Segal and Hao Xiong and Daniel Capurso and Mariel Vazquez and Javier Arsuaga},
  journal={Biostatistics},
  year={2014},
  volume={15 3},
  pages={442-56}
}
It is widely recognized that the three-dimensional (3D) architecture of eukaryotic chromatin plays an important role in processes such as gene regulation and cancer-driving gene fusions. Observing or inferring this 3D structure at even modest resolutions had been problematic, since genomes are highly condensed and traditional assays are coarse. However… CONTINUE READING