Reproducibility of [11 C]FLB 457 binding in extrastriatal regions.

  title={Reproducibility of [11 C]FLB 457 binding in extrastriatal regions.},
  author={Yasuhiko Sudo and Tetsuya Suhara and Makoto Inoue and Hiroshi Ito and Katsuaki Suzuki and Tomoyuki Saijo and Christer Halldin and Lars Farde},
  journal={Nuclear medicine communications},
  volume={22 11},
Extrastriatal D2 dopamine receptors represent an important target of research into the pathophysiology and pharmacotherapy of psychiatric disorders. The high affinity radioligand [11C]FLB 457 makes possible the measurement of low concentrations of D2 receptors in extrastriatal regions using positron emission tomography (PET). The aim of this study was to assess the test/retest variability and reliability of [11C]FLB 457 binding using a reference tissue model. Eight healthy male subjects (aged… CONTINUE READING