Reproducibility assessment of relative quantitation strategies for LC-MS based proteomics.

@article{Kim2007ReproducibilityAO,
  title={Reproducibility assessment of relative quantitation strategies for LC-MS based proteomics.},
  author={Yeoun jin Kim and Ping Zhan and Brian Feild and Steven M. Ruben and Tao He},
  journal={Analytical chemistry},
  year={2007},
  volume={79 15},
  pages={
          5651-8
        }
}
The reproducibility of a given method for relative quantitation governs the reliability of liquid chromatography-mass spectrometry (LC-MS) based differential analysis in proteomic studies. Understanding the noise level introduced from biological, chemical, and instrumental sources not only helps to determine the experimental design but also aids in assessing the reliability of expression ratios used for quantitation. Here we present a reproducibility assessment method for relative quantitation… 
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