Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease

  title={Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease},
  author={Francois De Guio and Eric Jouvent and Geert Jan Biessels and Sandra E. Black and Carol Brayne and Christopher Chen and Charlotte Cordonnier and Frank-Eric De Leeuw and Martin Dichgans and Fergus N. Doubal and Marco Duering and Carole Dufouil and Emrah Duzel and Franz Fazekas and Vladimir Hachinski and Mohammad Arfan Ikram and J. Linn and Paul M. Matthews and Bernard Mazoyer and Vincent Chung-Tong Mok and Bo Norrving and John Tiernan O'Brien and Leonardo Pantoni and Stefan Ropele and Perminder Singh Sachdev and Reinhold Schmidt and Sudha Seshadri and Eric E. Smith and Luciano A. Sposato and Blossom C M Stephan and Richard H. Swartz and Christophe Tzourio and M.A. van Buchem and Aad van der Lugt and Robert J. van Oostenbrugge and Meike W. Vernooij and Anand Viswanathan and David John Werring and Frank A. Wollenweber and Joanna Marguerite Wardlaw and Hugues Chabriat},
  journal={Journal of Cerebral Blood Flow \& Metabolism},
  pages={1319 - 1337}
Brain imaging is essential for the diagnosis and characterization of cerebral small vessel disease. Several magnetic resonance imaging markers have therefore emerged, providing new information on the diagnosis, progression, and mechanisms of small vessel disease. Yet, the reproducibility of these small vessel disease markers has received little attention despite being widely used in cross-sectional and longitudinal studies. This review focuses on the main small vessel disease-related markers on… 

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