Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease

@article{DeGuio2016ReproducibilityAV,
  title={Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease},
  author={Francois De Guio and Eric Jouvent and Geert Jan Biessels and Sandra E. Black and Carol Brayne and Christopher Chen and Charlotte Cordonnier and Frank-Eric De Leeuw and Martin Dichgans and Fergus N. Doubal and Marco Duering and Carole Dufouil and Emrah Duzel and Franz Fazekas and Vladimir Hachinski and Mohammad Arfan Ikram and J. Linn and Paul M. Matthews and Bernard Mazoyer and Vincent Chung-Tong Mok and Bo Norrving and John Tiernan O'Brien and Leonardo Pantoni and Stefan Ropele and Perminder Singh Sachdev and Reinhold Schmidt and Sudha Seshadri and Eric E. Smith and Luciano A. Sposato and Blossom C M Stephan and Richard H. Swartz and Christophe Tzourio and M.A. van Buchem and Aad van der Lugt and Robert J. van Oostenbrugge and Meike W. Vernooij and Anand Viswanathan and David John Werring and Frank A. Wollenweber and Joanna Marguerite Wardlaw and Hugues Chabriat},
  journal={Journal of Cerebral Blood Flow \& Metabolism},
  year={2016},
  volume={36},
  pages={1319 - 1337}
}
Brain imaging is essential for the diagnosis and characterization of cerebral small vessel disease. Several magnetic resonance imaging markers have therefore emerged, providing new information on the diagnosis, progression, and mechanisms of small vessel disease. Yet, the reproducibility of these small vessel disease markers has received little attention despite being widely used in cross-sectional and longitudinal studies. This review focuses on the main small vessel disease-related markers on… 

Tables from this paper

Advanced Neuroimaging of Cerebral Small Vessel Disease
TLDR
Advances in neuroimaging published since January 2015 are described, mainly with magnetic resonance imaging, that are improving quantification, observation and investigation of SVD focussing on three areas: quantifying the total SVD burden, imaging brain microstructural integrity and imaging vascular malfunction.
The Additional Value of PET in the Assessment of Cerebral Small Vessel Disease
  • W. Heiss
  • Medicine, Biology
    The Journal of Nuclear Medicine
  • 2018
TLDR
MRI remains the key neuroimaging modality and is preferred to CT in vascular cognitive impairment (VCI) because it has higher sensitivity and specificity for detecting pathologic changes and PET can support the clinical diagnosis by visualizing cerebral functions in typically affected brain regions.
Neuroimaging in Cerebral Small Vessel Disease
TLDR
Magnetic resonance imaging (MRI) remains the key neuroimaging modality and is preferred to CT in vascular cognitive impairment (VCI) because it has higher sensitivity and specificity for detecting pathological changes.
Quantitative and qualitative MRI evaluation of cerebral small vessel disease in an elderly population: a longitudinal study
TLDR
MRI manifestations of SVD progressed over five years in an elderly population and rCBF was not associated with WMH volume or progression of WMHVolume.
Investigating the origin and evolution of cerebral small vessel disease: The RUN DMC – InTENse study
TLDR
This study will provide a better understanding of the role of DWI+ lesions in the pathophysiology of SVD and will further unravel the structural and functional consequences and clinical importance of these lesions, with an unprecedented temporal resolution.
Cerebral microbleeds: from depiction to interpretation
TLDR
The present review addresses clinical dilemmas and the value of CMBs as diagnostic and prognostic markers for future vascular events and harmonising imaging parameters across research studies remains necessary to improve cross-study comparisons.
Using DTI to assess white matter microstructure in cerebral small vessel disease (SVD) in multicentre studies
Diffusion tensor imaging (DTI) metrics such as fractional anisotropy (FA) and mean diffusivity (MD) have been proposed as clinical trial markers of cerebral small vessel disease (SVD) due to their
New insights into cerebral small vessel disease and vascular cognitive impairment from MRI
TLDR
New, advanced quantitative neuroimaging techniques are not ready for routine radiological practice but are already being employed as monitoring biomarkers in the newest generation of trials for SVD.
Multicenter Imaging Studies: Automated Approach to Evaluating Data Variability and the Role of Outliers
TLDR
This work proposes a framework to analyze data variability and identify samples that should be removed in order to have more representative, reliable and robust datasets, and proposes an algorithm for assessing data robustness and finding the optimal data for study occlusion.
Cerebral small vessel disease: from a focal to a global perspective
TLDR
It is concluded that SVD should be considered a global rather than a focal disease, as the classically recognized focal lesions affect remote brain structures and structural and functional network connections, resulting in the variable presentation of SVD.
...
...

References

SHOWING 1-10 OF 132 REFERENCES
Current Concepts of Analysis of Cerebral White Matter Hyperintensities on Magnetic Resonance Imaging
TLDR
This section discusses future analytic methods designed to better understand the pathophysiology and cognitive consequences of WMHs, andStrengths and limitation of both quantitative and qualitative methods are discussed.
Clinical Relevance of Improved Microbleed Detection by Susceptibility-Weighted Magnetic Resonance Imaging
TLDR
SWI detected more MBs in more patients, irrespective of MB location, but this enhanced detection had no improved clinical relevance in terms of associations with vascular risk factors or radiologic markers of small-vessel disease.
White matter hyperintensities, cognitive impairment and dementia: an update
TLDR
A timely Review on WMHs, including their relationship with cognitive decline and dementia, is provided, although evidence for effective interventions is still lacking.
Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
Quantitative and qualitative assessment of structural magnetic resonance imaging data in a two-center study
TLDR
This study aimed to optimize a set of volumetric MRI-protocols to define a protocol giving data that are consistent and reproducible across two centers and over time, using FreeSurfer and Voxel Based Morphometry approaches.
MR Imaging Detection of Cerebral Microbleeds: Effect of Susceptibility-Weighted Imaging, Section Thickness, and Field Strength
TLDR
An analysis of sequence, section thickness, and field strength on CMB imaging properties and detection in subjects with cerebral amyloid angiopathy, a condition associated with microhemorrhage yields substantially improved CMB contrast and sensitivity for detection.
...
...