Reproducibility and variability of digital thermal monitoring of vascular reactivity

@article{Ahmadi2011ReproducibilityAV,
  title={Reproducibility and variability of digital thermal monitoring of vascular reactivity},
  author={Naser Ahmadi and Gary L. Mcquilkin and Mohammad W. Akhtar and Fereshteh Hajsadeghi and Stanley J. Kleis and Harvey S. Hecht and Morteza Naghavi and Matthew J. Budoff},
  journal={Clinical Physiology and Functional Imaging},
  year={2011},
  volume={31}
}
Background:  Previous studies demonstrated that digital thermal monitoring (DTM) of vascular reactivity, a new test for vascular function assessment, is well correlated with Framingham Risk Score, coronary calcium score and CT angiography. This study evaluates the variability and reproducibility of DTM measurements. We hypothesized that DTM is reproducible, and its variability falls within the accepted range of clinical diagnostic tests. 
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References

SHOWING 1-10 OF 39 REFERENCES
Relations between digital thermal monitoring of vascular function, the Framingham risk score, and coronary artery calcium score.
Guidelines for measurement of cutaneous blood flow by laser Doppler flowmetry
TLDR
Technical variation, instrument validation including a standard reactive hyperemia experiment, and a standard operating procedure are discussed and included in the guidelines.
Vascular dysfunction measured by fingertip thermal monitoring is associated with the extent of myocardial perfusion defect
  • N. Ahmadi, N. Usman, +9 authors M. Budoff
  • Medicine
    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
  • 2009
TLDR
Vascular dysfunction measured by DTM is associated with the extent of myocardial perfusion defect independent of age, gender, and cardiac risk factors.
Low fingertip temperature rebound measured by digital thermal monitoring strongly correlates with the presence and extent of coronary artery disease diagnosed by 64-slice multi-detector computed tomography
TLDR
In patients suspected of CAD, low fingertip temperature rebound measured by DTM significantly predicted CTA-diagnosed obstructive disease, and all DTM indices of vascular and neurovascular reactivity significantly decreased from normal to non-obstructive to obstructive CAD.
Flow mediated dilation of the brachial artery: an investigation of methods requiring further standardization
TLDR
These findings suggest that forearm compression holds statistical advantages over upper arm compression and it is proposed that future studies should use forearm compression in the assessment of endothelium-dependent flow mediated dilation.
Novel temperature based technique for measurement of endothelial dysfunction
TLDR
This work proposes to measure the endothelial dysfunction (EDF) by causing reactive hyperemia in the arm and measuring the temperature variations of the hand region, using a computer-based data acquisition system.
Methodological approaches to optimize reproducibility and power in clinical studies of flow-mediated dilation.
...
1
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3
4
...