Reproducibility and temporal stability of ADP-induced platelet aggregation: comparison of the anticoagulants sodium citrate and D-phenylalanyl-L-prolyl-L-arginyl-chloromethyl ketone.

@article{Horne1991ReproducibilityAT,
  title={Reproducibility and temporal stability of ADP-induced platelet aggregation: comparison of the anticoagulants sodium citrate and D-phenylalanyl-L-prolyl-L-arginyl-chloromethyl ketone.},
  author={William C. Horne and George M. Anderson and Donald J. Cohen},
  journal={American journal of hematology},
  year={1991},
  volume={38 1},
  pages={48-53}
}
We compared the reproducibility and temporal stability of ADP-induced aggregation of platelet-rich plasma anticoagulated with citrate or with D-phenylalanyl-L-prolyl-L-arginyl-chloromethyl ketone (PPACK), a thrombin inhibitor. Citrate- or PPACK-platelet-rich plasma (PRP) was stored at room temperature in capped plastic tubes or in plastic syringes from which all air was expelled. At intervals over 1-5 hr after venipuncture, platelet aggregation was induced by 1-1.5 microM ADP. Initially, the… CONTINUE READING

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Reproducibility and temporal stability of ADP - induced platelet aggregation : comparison of the anticoagulants sodium citrate and D - phenylalanyl - L - prolyl - L - arginyl - chloromethyl ketone .
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