Reproducibility and Reuse of Adaptive Immune Receptor Repertoire Data

  title={Reproducibility and Reuse of Adaptive Immune Receptor Repertoire Data},
  author={Felix Breden and Eline T. Luning Prak and Bjoern Peters and Florian Rubelt and Chaim A. Schramm and Christian E. Busse and Jason A. Vander Heiden and Scott Christley and Syed Ahmad Chan Bukhari and Adrian Thorogood and Frederick A Matsen Iv and Yariv Wine and Uri Laserson and David Klatzmann and Daniel C. Douek and Marie-Paule Lefranc and Andrew M. Collins and Tania Bubela and Steven H. Kleinstein and Corey T. Watson and Lindsay G. Cowell and Jamie K. Scott and Thomas B. Kepler},
  journal={Frontiers in Immunology},
High-throughput sequencing (HTS) of immunoglobulin (B-cell receptor, antibody) and T-cell receptor repertoires has increased dramatically since the technique was introduced in 2009 (1–3). This experimental approach explores the maturation of the adaptive immune system and its response to antigens, pathogens, and disease conditions in exquisite detail. It holds significant promise for diagnostic and therapy-guiding applications. New technology often spreads rapidly, sometimes more rapidly than… 

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