Repressor element 1 silencing transcription factor couples loss of pluripotency with neural induction and neural differentiation.

@article{Soldati2012RepressorE1,
  title={Repressor element 1 silencing transcription factor couples loss of pluripotency with neural induction and neural differentiation.},
  author={Chiara Soldati and Angela Bithell and Caroline Johnston and Kee-Yew Wong and Siaw-Wei Teng and Vassilios Beglopoulos and Lawrence Walter Stanton and Noel J. Buckley},
  journal={Stem cells},
  year={2012},
  volume={30 3},
  pages={425-34}
}
Neural differentiation of embryonic stem cells (ESCs) requires coordinated repression of the pluripotency regulatory program and reciprocal activation of the neurogenic regulatory program. Upon neural induction, ESCs rapidly repress expression of pluripotency genes followed by staged activation of neural progenitor and differentiated neuronal and glial genes. The transcriptional factors that underlie maintenance of pluripotency are partially characterized whereas those underlying neural… CONTINUE READING

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