Repressor activity of Headless/Tcf3 is essential for vertebrate head formation

@article{Kim2000RepressorAO,
  title={Repressor activity of Headless/Tcf3 is essential for vertebrate head formation},
  author={Cheol-Hee Kim and Takaya Oda and Motoyuki Itoh and Di Jiang and Kristin Bruk Artinger and Settara C. Chandrasekharappa and Wolfgang Driever and Ajay B. Chitnis},
  journal={Nature},
  year={2000},
  volume={407},
  pages={913-916}
}
The vertebrate organizer can induce a complete body axis when transplanted to the ventral side of a host embryo by virtue of its distinct head and trunk inducing properties. Wingless/Wnt antagonists secreted by the organizer have been identified as head inducers. Their ectopic expression can promote head formation, whereas ectopic activation of Wnt signalling during early gastrulation blocks head formation. These observations suggest that the ability of head inducers to inhibit Wnt signalling… Expand
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