Repression of the soma-specific transcriptome by Polycomb-repressive complex 2 promotes male germ cell development.

@article{Mu2014RepressionOT,
  title={Repression of the soma-specific transcriptome by Polycomb-repressive complex 2 promotes male germ cell development.},
  author={Weipeng Mu and J. Starmer and Andrew M. Fedoriw and Della Yee and Terry Magnuson},
  journal={Genes & development},
  year={2014},
  volume={28 18},
  pages={2056-69}
}
Polycomb-repressive complex 2 (PRC2) catalyzes the methylation of histone H3 Lys27 (H3K27) and functions as a critical epigenetic regulator of both stem cell pluripotency and somatic differentiation, but its role in male germ cell development is unknown. Using conditional mutagenesis to remove the core PRC2 subunits EED and SUZ12 during male germ cell development, we identified a requirement for PRC2 in both mitotic and meiotic germ cells. We observed a paucity of mutant spermatogonial stem… CONTINUE READING
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