Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta.

@article{Stein1995RepressionOT,
  title={Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta.},
  author={Bernd Stein and Ms. Xiaowei Yang},
  journal={Molecular and cellular biology},
  year={1995},
  volume={15 9},
  pages={4971-9}
}
Bone metabolism is regulated by a balance between bone resorption caused by osteoclasts and bone formation caused by osteoblasts. This balance is disturbed in postmenopausal women as a result of lower serum estrogen levels. Estrogen, which is used in hormone replacement therapy to prevent postmenopausal osteoporosis, downregulates expression of the interleukin 6 (IL-6) gene in osteoblasts and bone marrow stromal cells. IL-6 is directly involved in bone resorption by activating immature… CONTINUE READING
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