Repression of the human dihydrofolate reductase gene by a non-coding interfering transcript

@article{Martianov2007RepressionOT,
  title={Repression of the human dihydrofolate reductase gene by a non-coding interfering transcript},
  author={Igor Martianov and Aroul Ramadass and Ana Serra Barros and Natalie Chow and Alexandre Akoulitchev},
  journal={Nature},
  year={2007},
  volume={445},
  pages={666-670}
}
Alternative promoters within the same gene are a general phenomenon in gene expression. Mechanisms of their selective regulation vary from one gene to another and are still poorly understood. Here we show that in quiescent cells the mechanism of transcriptional repression of the major promoter of the gene encoding dihydrofolate reductase depends on a non-coding transcript initiated from the upstream minor promoter and involves both the direct interaction of the RNA and promoter-specific… 
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