Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas.

@article{Baron2007RepressionOT,
  title={Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas.},
  author={Beverly W Baron and Nancy J. Zeleznik-Le and Miriam J. Baron and Catherine M Theisler and Dezheng Huo and Matthew D. Krasowski and Michael Thirman and Rebecca Baron and Joseph M. Baron},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 18},
  pages={7449-54}
}
The human BCL6 gene on chromosome 3 band q27, which encodes a transcriptional repressor, is implicated in the pathogenesis of human lymphomas, especially the diffuse large B-cell type. We previously identified the human PDCD2 (programmed cell death-2) gene as a target of BCL6 repression. PDCD2 encodes a protein that is expressed in many human tissues, including lymphocytes, and is known to interact with corepressor complexes. We now show that BCL6 can bind directly to the PDCD2 promoter… CONTINUE READING

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