Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53

@article{Zalcenstein2006RepressionOT,
  title={Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53},
  author={Amir Zalcenstein and Lilach Weisz and Perry Stambolsky and Jair Bar and Varda Rotter and Moshe Oren},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={359-369}
}
Tumor-associated mutant forms of p53 can exert an antiapoptotic gain of function activity, which confers a selective advantage upon tumor cells harboring such mutations. We report that mutant p53 suppresses the expression of the MSP (MST-1/HGFL) gene, encoding the ligand of the receptor tyrosine kinase RON, implicated in a variety of cellular responses. Mutant p53 associates with the MSP gene promoter and represses its transcriptional activity, leading to a decrease in mRNA levels and a… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 25 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 14 REFERENCES

Nucleic Acids Res 33: 1087–1100

  • W.
  • Gualberto A, Aldape K, Kozakiewicz K, Tlsty TD…
  • 2005
Highly Influential
5 Excerpts

Cancer Res 64: 5154–5161

  • GN Ranzani
  • Bargonetti J, Manfredi JJ. (). Curr Opin Oncol 14…
  • 2004

Cancer Res 64: 7447–7454

  • MF Miles
  • Serrano M. (). Carcinogenesis 21: 865–869. Sigal…
  • 2004

Neoplasia 6: 1–6

  • D Ghosh
  • Sakamoto O, Iwama A, Amitani R, Takehara T…
  • 2004

Oncogene 23: 4430–4443

  • A Das
  • Scian MJ, Stagliano KE, Ellis MA, Hassan S…
  • 2004

Cell Death Differ 10: 431–442

  • M. Oren
  • Cancer Res
  • 2003
2 Excerpts

J Invest Dermatol 120: 865–870

  • RT, S. Kohler
  • Vogelstein B, Lane D, Levine AJ. (). Nature 408…
  • 2003

Oncogene 22: 5667–5676

  • TM Goncharov
  • Zastawny RL, Salvino R, Chen J, Benchimol S, Ling…
  • 2003

EMBO J 20: 4163–4172

  • D Schwartz
  • Miller AD, Van Hoeven NS, Liu SL. (). BMC Cancer…
  • 2001

Nature 412: 822–826

  • S ally, K Kurachi
  • Dippold W
  • 2001

Similar Papers

Loading similar papers…