Repression of the Id2 (inhibitor of differentiation) gene promoter during exit from the cell cycle.

@article{Biggs1995RepressionOT,
  title={Repression of the Id2 (inhibitor of differentiation) gene promoter during exit from the cell cycle.},
  author={Joseph R. Biggs and Yinghua Zhang and Etain Murphy},
  journal={Journal of cellular physiology},
  year={1995},
  volume={164 2},
  pages={249-58}
}
The Id2 gene is one of several "Id-like" genes which encode helix-loop-helix proteins which dimerize with basic helix-loop-helix proteins and inhibit binding to the DNA enhancer element known as an E box. By repressing the DNA binding activity of basic helix-loop-helix proteins, Id proteins inhibit transcription of tissue-specific genes in myoblasts, hematopoietic precursor cells, and other types of undifferentiated cells. Serum starvation results in the disappearance of Id gene transcripts in… CONTINUE READING