Repression of the DNA-binding inhibitor Id3 by Blimp-1 limits CD8+ T cell memory formation

Abstract

The transcriptional repressor Blimp-1 promotes the differentiation of CD8+ T cells into short-lived effector cells (SLECs) that express the lectin-like receptor KLRG-1, but how it operates remains poorly defined. Here we show that Blimp-1 bound to and repressed the promoter of the gene encoding the DNA-binding inhibitor Id3 in SLECs. Repression of Id3 by… (More)
DOI: 10.1038/ni.2153

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