Repression of tau hyperphosphorylation by chronic endurance exercise in aged transgenic mouse model of tauopathies.

@article{Leem2009RepressionOT,
  title={Repression of tau hyperphosphorylation by chronic endurance exercise in aged transgenic mouse model of tauopathies.},
  author={Yea-Hyun Leem and Hwa-Ja Lim and Sun-Bo Shim and Joon-Yong Cho and Bum-soo Kim and Peiqing Han},
  journal={Journal of neuroscience research},
  year={2009},
  volume={87 11},
  pages={
          2561-70
        }
}
The present study was undertaken to investigate whether chronic endurance exercise affects tau phosphorylation levels in the brain with Alzheimer's disease (AD)-like pathology. To address this, the transgenic (Tg) mouse model of tauopathies, Tg-NSE/htau23, which expresses human tau23 in the brain, was chosen. Animals were subjected to chronic exercise for 3 months from 16 months of age. The exercised Tg mouse groups were treadmill run at speeds of 12 m/min (intermediate exercise group) or 19 m… CONTINUE READING
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