Repression of tau hyperphosphorylation by chronic endurance exercise in aged transgenic mouse model of tauopathies.

  title={Repression of tau hyperphosphorylation by chronic endurance exercise in aged transgenic mouse model of tauopathies.},
  author={Yea-Hyun Leem and Hwa-Ja Lim and Sun-Bo Shim and Joon-Yong Cho and Bum-soo Kim and Peiqing Han},
  journal={Journal of neuroscience research},
  volume={87 11},
The present study was undertaken to investigate whether chronic endurance exercise affects tau phosphorylation levels in the brain with Alzheimer's disease (AD)-like pathology. To address this, the transgenic (Tg) mouse model of tauopathies, Tg-NSE/htau23, which expresses human tau23 in the brain, was chosen. Animals were subjected to chronic exercise for 3 months from 16 months of age. The exercised Tg mouse groups were treadmill run at speeds of 12 m/min (intermediate exercise group) or 19 m… CONTINUE READING
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Publications referenced by this paper.
Showing 1-10 of 50 references

Hormetic effects of regular exercise in aging: correlation with oxidative stress

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme • 2007
View 4 Excerpts
Highly Influenced

GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt.

The European journal of neuroscience • 2006
View 2 Excerpts
Highly Influenced

Wnt signaling in disease and in development

Cell Research • 2005
View 3 Excerpts
Highly Influenced

Behavioral stress enhances Alzheimer’s disease pathogenesis via metabolic oxidative stress

KW Lee, JB Kim, +6 authors PL. Han
J Neurochem 108:165–175. • 2009
View 2 Excerpts