Repression of somatostatin gene transcription mediated by two promoter silencer elements.

Abstract

We report that expression of the somatostatin gene in pancreatic islets and in non-islet cells is negatively regulated by two proximal silencer elements, PS1 and PS2. Transient transfection assays showed that PS1 decreases somatostatin gene promoter activity stimulated by an upstream enhancer in the islet D-cell line RIN-1027-B2, but not in the islet B-cell… (More)

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